Effects of Fixed Low-Dose Warfarin, Aspirin-Warfarin Combination Therapy, and Dose-Adjusted Warfarin on Thrombogenesis in Chronic Atrial Fibrillation
نویسندگان
چکیده
منابع مشابه
Effects of fixed low-dose warfarin, aspirin-warfarin combination therapy, and dose-adjusted warfarin on thrombogenesis in chronic atrial fibrillation.
BACKGROUND AND PURPOSE Recent clinical trials have established that adjusted-dose warfarin (international normalized ratio [INR] 2.0 to 3.0) is highly effective in the reduction of ischemic stroke in patients with nonvalvular atrial fibrillation (AF). We hypothesized that the introduction of fixed low-dose warfarin alone or in combination with aspirin (300 mg) could normalize hemostatic markers...
متن کاملA prospective randomized trial of aspirin-clopidogrel combination therapy and dose-adjusted warfarin on indices of thrombogenesis and platelet activation in atrial fibrillation.
OBJECTIVES This study was designed to investigate whether or not combination aspirin-clopidogrel therapy would reduce markers of thrombogenesis and platelet activation in atrial fibrillation (AF), in a manner similar to warfarin. BACKGROUND Dose-adjusted warfarin is beneficial as thromboprophylaxis in AF, but potentially serious side effects and regular monitoring leave room for alternative t...
متن کاملWarfarin Versus Warfarin and Aspirin in Atrial Fibrillation
Background Anticoagulation with warfarin is an important therapy for preventing strokes in patients with atrial fibrillation (AF). Physicians often combine warfarin with aspirin despite evidence for increased bleeding. We investigated the hemorrhagic outcomes related to the differential management of AF with warfarin alone versus combination therapy. Methods and Results This retrospective cohor...
متن کاملWarfarin discontinuation after starting warfarin for atrial fibrillation.
BACKGROUND Although warfarin is widely recommended to prevent atrial fibrillation-related thromboembolism, many eligible patients do not take warfarin. The objective of this study was to describe factors associated with warfarin discontinuation in patients newly starting warfarin for atrial fibrillation. METHODS AND RESULTS We identified 4188 subjects newly starting warfarin in the Anticoagul...
متن کاملNon-rheumatic atrial fibrillation: warfarin or aspirin for all?
Stroke is the third most common cause of death in the United Kingdom after ischaemic heart disease and cancer. Disabled patients who survive an acute stroke place a great social and economic burden on the community-stroke prevention is therefore a priority. Cerebral infarction accounts for almost 80% of all first strokes. A significant proportion of these are embolic in origin and associated wi...
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ژورنال
عنوان ژورنال: Stroke
سال: 2000
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.31.4.828